Effectiveness of Preventive of Fresh Pineapple Juice Against the Genotoxicity Effects of Ifosfamide on albino Mice

The present study aim to evaluate the ability of fresh pineapple juice against the genotoxicity side effects of Ifosfamide anti-cancer drug. It was done through using the dominant lethal mutations, one of the short-term tests that adopted in such studies. The results of this study showed that there was a significant reduction of the total and live implants in some weeks and a high morale significant of the other weeks being tested. There was also a significant increase or a high morale significant in the number of dead embryos at an early stage of growth. The toxicity of Ifosfamide induced dominant lethal mutations which markedly appeared during the 1,2,3 and 5 weeks mating periods, this implies that the early spermatids, primary spermatocytes and spermatozoa and late spermatids were the most affected stages by this treatment. On the other hand the dual treatment with pineapple and Ifosfamide caused marked increase in fertility index and total number of implantation and live implants, a noticeable decrease in the numbers of early dead embryos. This represented that the oral administration of pineapple was found to be effective in reducing the dominant lethal mutations values in the early spermatids , primary spermatocytes and spermatozoa and late spermatids stages , which are the same cytological stages affected by Ifosfamide treatment only